19.  GENERALLY APPLICABLE REQUIREMENTS.

In accordance with 10 CFR 600.12, this grant is subject to a number of statutory and other generally applicable requirements.  Those requirements most pertinent to research projects are highlighted below:

a.  Research Involving Vertebrate Animals. Any recipient performing research on vertebrate animals shall comply with the Laboratory Animal Welfare Act of 1966, as amended (7 U.S.C. 2131 et seq.), and the regulations promulgated thereunder by the Secretary of Agriculture (9 CFR) pertaining to the care, handling, and treatment of vertebrate animals held or used for research, teaching, or other activities supported by Federal awards. The recipient is expected to ensure that the guidelines described in Department of Health and Human Services (DHHS) Publication No. (NIH) 85-23, “Guide for the Care and Use of Laboratory Animals,” are followed and to comply with the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research and Training (included as an Appendix to the NIH Guide).

b.  Research Involving Recombinant DNA Molecules.  Any grantee performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules agrees by acceptance of this grant to comply with the National Institutes of Health  “Guidelines for Research Involving Recombinant DNA Molecules,” 6-83 (48 FR 24556) or such later revision to those guidelines as may be published in the Federal Register.

c.  Use of Human Subjects in Research. Development. and Related Activities. Any DOE grantee performing research, development, or related activities involving human subjects must comply with regulations found at 10 CFR Part 745, “Protection of Human Subjects,” and any additional provisions which may be included in the “Special Terms and Conditions” of the grant.  Such provisions are intended to safeguard the rights and welfare of human subjects at risk of possible physical, psychological, or social injury as a consequence of their participation.