Genome Analysis Tools and Information Services--Genome Informatics Corporation, 1020 Commerce Park Drive, Oak Ridge, TN 37830; 423-220-0043
Mr. Doug Hyatt, Principal Investigator
Dr. Ed Uberbacher, Business Official
DOE Grant No. DE-FG02-99ER82794
Amount: $600,000

Knowledge about genomes is rapidly becoming a central driver for product development in phar-maceutical and biotechnology industries. Many companies lack the tools, infrastructure and information to take full advantage of the flood of genome data and would greatly benefit from easy-to-access genome analysis tools and infor-mation about genome content. This project will develop and deploy a suite of analysis tools and a series of information services that will provide valuable insights into genes and gene function. The Phase I project restructured a gene discovery code for higher modularity, improved algorithms, and computational efficiency. In addition, a Java interface was constructed, databases were pack-aged for support of the software, and a command-line applications programming inter-face was created. Phase II will develop a comprehensive genome analysis tool suite and pipeline for deployment at remote sites, a data warehousing system that allows users to manage and integrate these data at their sites, and software to provide users with views of annotated genomes. These tools and services will be de-ployed via public and private secure networks.

Commercial Applications and Other Benefits as described by the awardee: These software tools should allow the sequence data produced by DOE and other federal agencies to be used for important medical and environmental applications such as diagnostics, drug design, and bioremediation. The use of these tools should also further the development of the rapidly growing U.S. industry segment focused on biotechnology, bioengineering, and genetic medicine.