Versatile Liquid Crystal Tunable Interference Filter for Chromosome Analysis--Physical Optics Corporation, 20600 Gramercy Place, Building 100, Torrance, CA 90501-1821; 310-320-3088
Dr. Tin Aye, Principal Investigator
Mr. Gordon Drew, Business Official
DOE Grant No. DE-FG03-99ER82856
Amount: $749,998

High resolution spectral imaging microscopy using multi-probe fluorescence in situ hybridization (FISH) has been demonstrated as a potential technique for chromosome analysis. However, current spectral imaging systems are limited in the number of chromosomes that can be probed simultaneously. This project will develop a highly versatile, high resolution, wide spectral range, high speed, liquid crystal tunable interference filter (LCTIF) to overcome the limitations of current spectral imaging techniques used with FISH. The Phase I project designed the liquid crystal tunable interference filter components, analyzed their performance, and verified the concept by experimental demonstrations. Also, the fabrication process by which the proposed device can be manufactured was investigated, and the feasibility of the concept was demonstrated. Phase II will optimize the design and develop a fully-operational prototype system for the liquid crystal tunable interference filter with high speed tunability over a broad spectral range (from visible to near infrared), with high out-of-band rejection. The system will be tested and evaluated in terms of its suitability for future DOE multiprobe gene mapping projects and for commercial applications.

Commercial Applications and Other Benefits as described by the awardee: Commercial applications include tunable spectral filters for spectral imaging microscopy, and other multispectral imaging sensor applications, both for sale to OEMs and as stand-alone instruments. Its low cost, high speed, and broadband continuous tuning make it suitable for spectral sensing in field use, including in hazardous environments and factories.