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PRISM: Software
for Protein Structure and Function—BioSequent, LLC,
Mr. Edwin R.
Addison, Principal Investigator, ed@edaddison.com
Mr. Edwin R.
Addison, Business Official, ed@edaddison.com
DOE Grant No.
DE-FG02-03ER83611
There has
been an explosion of new genome sequencing and data in the field of
bioinformatics. However, the
determination of protein structure and function is lagging behind the pace of
data generation. Software and
algorithms are needed to speed this process and improve its accuracy.
This project will develop a software system called PRISM (PRotein
Integration of Sequence Metrics), which combines evidence from multiple sources
and databases, using an evidential reasoning calculus to produce better
hypotheses and conclusions about protein structure and functional assignment.
A prototype of PRISM will be developed and tested in Phase I.
A complete and comprehensive system covering many features will be
developed in Phase II and will be the basis of a future commercial product.
Commercial
Applications and Other Benefits as described by awardee:
Bioinformatics software and services, related to genomes, protein
structure, and function-determination should be provided to pharmaceutical
companies, biotech companies, medical research institutions, and government
agencies.