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Rapid Microfluidic
Mr. Joseph Carl Matteo,
Ms. Debbie M. Matteo, Business
Official, jdmatteo@direcway.com
DOE Grant No. DE-FG02-05ER84290
Amount: $99,638
The DOE has expressed a need
for novel probes for biomedical applications as well as radio tracers for
functional molecular imaging. Synthesis
of novel probes and radiotracers, particularly new PET biomarkers, is difficult
and costly and is limiting the utility of PET imaging technology. There is a need for rapid production of
multiple and novel biomakers with PET radiolabels from a single synthesis
device, which can be routinely operated by clinical and research staff. This project will develop a microfluidic
platform for high speed organic synthesis and flow-based purification of PET
biomarkers, with closed-loop feedback for continuous yield optimization. The device will be capable of producing
multiple biomarkers in less than 60 seconds by operating in parallel with
interchangeable cartridges. Only
microliter quantities of reagents will
be consumed and minimal user setup will be required. In Phase I, the microfluidic circuit will be
designed to support closed-loop production of biomarkers with [F-18] fluoride
ion labels. A prototype synthesis
platform will be fabricated, characterized, and used to synthesize fluorodeoxyglucose
(FDG) as a demonstration of feasibility.
Commercial Applications and Other Benefits as described by the awardee: The microfluidic synthesis platform should enable